Outwitting Evolution¶

Goldberg, D. E., Siliciano, R. F., & Jacobs, W. R. (2012). Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV. Cell, 1271-1283.

Type: Journal article
Intellectual base: Primary research
Year: 2012
Pages: 1271-1283
DOI: 10.1016/j.cell.2012.02.021
DOI registrant: Elsevier
Link: https://doi.org/10.1016/j.cell.2012.02.021
Cited from: biology_ecology

Cited by¶

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes¶

Vaccine Escape
- The prime's diagnosis dictates the interventions: combination therapy (cocktails requiring simultaneous resistance, as in TB and HIV regimens), cycling (rotation), full suppressive dosing (reduce the sub-lethal selection that selects without killing), and stewardship (treat fewer cases to lower cumulative pressure).
  This sourceCombination therapy, cycling, full suppressive dosing, and stewardship as the intervention family against resistance.
  
  Supported in partVerified against the work's full text
  
  The review backs combination therapy against TB and HIV resistance and links suboptimal drug levels to selection; it does not present cycling or stewardship as strategies.
  
  “Combination therapy is clearly indispensible to treating TB and preventing resistance.”
  From the work's full text.
  
  Read by an automated reader; not a human review. How support was checked

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