Kinetics of pharmacologic response

Wagner, J. G. (1968). Kinetics of pharmacologic response. Journal of Theoretical Biology, 20(2), 173-201.

Type

Journal article

Intellectual base

Primary research

Year

1968

Link

no authoritative link yet

Cited from

pharmacology_toxicology

Cited by

2 citations across 2 artifacts.

Each citation links to the sentence it supports in the citing article.

Primes

• PK/PD Modeling (Pharmacokinetics / Pharmacodynamics)
  • The resolution requires mechanistic diagnostics (hysteresis plots, effect-compartment analysis) and willingness to adopt more complex structures when data warrant.

    This sourceDerivation of the Emax (sigmoid hyperbolic) concentration-response form from receptor-occupancy theory; canonical direct-response PD structure whose misspecification (versus indirect-response or tolerance) underlies T2 model-structure failures.

• Receptor Saturation
  • As Wagner (1968) formalized in his derivation of the E_max dose-response model,

    This sourceDerivation of the Emax (sigmoid hyperbolic) concentration-response form from receptor-occupancy theory; canonical direct-response PD structure whose misspecification (versus indirect-response or tolerance) underlies T2 model-structure failures.

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Registry ID ref:e1a8f658d787 · see in the full table