Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits¶
Tatti, R., Haley, M. S., Swanson, O. K., Tselha, T., & Maffei, A. (2017). Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits. Biological Psychiatry, 81(10), 821-831.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Excitation-Inhibition Balance
- The role mapping is consistent: the two channels map to glutamate and GABA, to activator and repressor, to enabling and checking powers, to predator and resource, to accelerator and brake; the combining operation maps to synaptic summation, to net transcription, to net policy effect; the co-modulation rule maps to whatever holds the ratio as overall input scales; and the failure asymmetry maps identically to seizure-versus-coma, oncogenesis-versus-silencing, runaway-versus-paralysis.
This sourceReviews the co-regulation of excitatory and inhibitory inputs onto principal neurons — channels, their combination, and the asymmetric consequences of shifting the balance — establishing the E/I role-mapping within neocortical circuits.
Supported in partVerified against the work's full text
The review supports only the neuroscience instances: glutamate-excitation and GABA-inhibition co-regulated in cortex, with disinhibition producing epileptic hyperexcitability; the cross-domain mappings are not in it.
“In neocortex, the balance between activity and stability relies on the co-regulation of excitatory and inhibitory inputs onto principal neurons.”
- The role mapping is consistent: the two channels map to glutamate and GABA, to activator and repressor, to enabling and checking powers, to predator and resource, to accelerator and brake; the combining operation maps to synaptic summation, to net transcription, to net policy effect; the co-modulation rule maps to whatever holds the ratio as overall input scales; and the failure asymmetry maps identically to seizure-versus-coma, oncogenesis-versus-silencing, runaway-versus-paralysis.
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