Mapping the Antigenic and Genetic Evolution of Influenza Virus¶
Smith, D. J., Lapedes, A. S., de Jong, J. C., Bestebroer, T. M., Rimmelzwaan, G. F., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2004). Mapping the Antigenic and Genetic Evolution of Influenza Virus. Science, 305(5682), 371-376.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Inoculation Theory
- The generalization window is cross-reactivity: memory that responds to related strains, not only the exact antigen presented, with coverage bounded by antigenic drift — the biological form of the prime's generalization gap, where a sufficiently mutated strain escapes the trained response.
This sourceQuantifies antigenic drift, the biological form of the generalization gap where a mutated strain escapes the trained immune response.
- The generalization window is cross-reactivity: memory that responds to related strains, not only the exact antigen presented, with coverage bounded by antigenic drift — the biological form of the prime's generalization gap, where a sufficiently mutated strain escapes the trained response.
- Vaccine Escape
- In infectious disease it is the antigen variant the vaccine-induced antibody no longer binds, and the strain existing immunity does not neutralize.
This sourceAntigenic drift as cumulative selection driving variants away from existing immunity; the antigen-variant escape case.
- In infectious disease it is the antigen variant the vaccine-induced antibody no longer binds, and the strain existing immunity does not neutralize.
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