The New Frontier of Genome Engineering with CRISPR-Cas9¶
Doudna, J. A., & Charpentier, E. (2014). The New Frontier of Genome Engineering with CRISPR-Cas9. Science, 346(6213).
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Defect
- Carried into biology, point mutations are defects with macroscopic genetic consequences, and gene therapy and CRISPR are defect-engineering interventions on the genome's regular structure.
This sourceReviews programmable RNA-guided CRISPR-Cas9 genome editing — targeted intervention on a specific genomic locus, i.e., defect engineering on the genome's regular structure rather than redesigning the bulk.
Supported in partVerified against the publisher's abstract
The abstract covers only the CRISPR half: programmable Cas9 editing of specific genomic loci, not the claim that point mutations are macroscopic defects or that gene therapy is defect engineering.
“We review the history of CRISPR (clustered regularly interspaced palindromic repeat) biology from its initial discovery through the elucidation of the CRISPR-Cas9 enzyme mechanism, which has set the stage for remarkable developments using this technology to modify, regulate, or mark genomic loci in a wide variety of cells and organisms from all three domains of life.”
- Carried into biology, point mutations are defects with macroscopic genetic consequences, and gene therapy and CRISPR are defect-engineering interventions on the genome's regular structure.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Read against the text for 1 of 1 citation: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:e7505b0e4959 · see in the full table