Simultaneous Modeling of Pharmacokinetics and Pharmacodynamics¶
Sheiner, L. B., Stanski, D. R., Vozeh, S., Miller, R. D., & Ham, J. (1979). Simultaneous Modeling of Pharmacokinetics and Pharmacodynamics: Application to d-Tubocurarine.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Mechanisms¶
- Effect-Compartment Lag Model
- Now the model can tell the anesthesiologist something the raw blood level cannot: that a bolus will keep deepening anesthesia after the concentration peaks, so the next dose should wait for the effect site to catch up rather than chase the blood number.
This sourceIntroduces a hypothetical effect compartment to model the temporal delay between plasma concentration and observed drug effect during nonequilibrium conditions.
- Now the model can tell the anesthesiologist something the raw blood level cannot: that a bolus will keep deepening anesthesia after the concentration peaks, so the next dose should wait for the effect site to catch up rather than chase the blood number.
Verification¶
Does it exist? Not checked yet. This entry carries no identifier to resolve. It was extracted from the citation as written in the article, normalized, and deduplicated against the rest of the registry.
Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
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Registry ID ref:e7cf6bfb25d1 · see in the full table