Update: use of the benchmark dose approach in risk assessment¶
EFSA Scientific Committee. (2017). Update: use of the benchmark dose approach in risk assessment. EFSA Journal.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- NOAEL (No Observed Adverse Effect Level)
- Modern alternatives to the NOAEL/LOAEL approach, particularly the benchmark dose (BMD) method endorsed by international regulatory bodies, fit a dose-response model to the full dataset and derive a dose producing a predetermined small response (typically 1% or 10% above background), which is more statistically stable and uses all the data rather than categorising doses as binary pass/fail
This sourceEFSA's reconfirmation that the benchmark dose approach is 'a scientifically more advanced method compared to the NOAEL approach for deriving a Reference Point', with dose-response models fitted to the dataset and the BMD confidence interval reported; it does not state the 1%-or-10% benchmark response the sentence quotes.
Supported in partVerified against the source
- Modern alternatives to the NOAEL/LOAEL approach, particularly the benchmark dose (BMD) method endorsed by international regulatory bodies, fit a dose-response model to the full dataset and derive a dose producing a predetermined small response (typically 1% or 10% above background), which is more statistically stable and uses all the data rather than categorising doses as binary pass/fail
Verification¶
Does it exist? Not checked yet. This entry carries no identifier to resolve. It was extracted from the citation as written in the article, normalized, and deduplicated against the rest of the registry.
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Registry ID ref:e8e6e90ef4b6 · see in the full table