Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors.¶
Takahashi, K., & Yamanaka, S. (2006). Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Cell, 126(4), 663-676.
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- … stage from the programme), perturbation analysis (a lesion at the progenitor stage propagates to every downstream cell type, which is why early-stage disruption is most consequential), reversibility (normally irreversible, though reprogramming experiments are precisely attempts to violate the directedness
This sourceDemonstrates reprogramming that violates the normal directedness/irreversibility of differentiation — the canonical attempt to run development backward.
- … stage from the programme), perturbation analysis (a lesion at the progenitor stage propagates to every downstream cell type, which is why early-stage disruption is most consequential), reversibility (normally irreversible, though reprogramming experiments are precisely attempts to violate the directedness
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