Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors.

Takahashi, K., & Yamanaka, S. (2006). Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Cell, 126(4), 663-676.

Type

Journal article

Intellectual base

Primary research

Year

2006

Volume

126

Issue

4

Pages

663-676

DOI

10.1016/j.cell.2006.07.024

DOI registrant

Elsevier

Link

https://doi.org/10.1016/j.cell.2006.07.024

Cited from

biology_ecology

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Develops-From Relation
  • … stage from the programme), perturbation analysis (a lesion at the progenitor stage propagates to every downstream cell type, which is why early-stage disruption is most consequential), reversibility (normally irreversible, though reprogramming experiments are precisely attempts to violate the directedness

    This sourceDemonstrates reprogramming that violates the normal directedness/irreversibility of differentiation — the canonical attempt to run development backward.

    Supported in partVerified against the work's full text

    Takahashi and Yamanaka show that differentiated fibroblasts can be reprogrammed to pluripotency with four factors, which is the reprogramming experiment the reversibility point relies on.

    “that pluripotent stem cells can be directly gen- erated from fibroblast cultures by the addition”

    Read by an automated reader; not a human review. How support was checked

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