Hematopoiesis

Orkin, S. H., & Zon, L. I. (2008). Hematopoiesis: An Evolving Paradigm for Stem Cell Biology. Cell, 132(4), 631-644.

Type

Journal article

Intellectual base

Primary research

Year

2008

Volume

132

Issue

4

Pages

631-644

DOI

10.1016/j.cell.2008.01.025

DOI registrant

Elsevier

Link

https://doi.org/10.1016/j.cell.2008.01.025

Cited from

biology_ecology

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Develops-From Relation
  • Trace a mature neutrophil back: it develops from a myeloblast, which develops from a common myeloid progenitor, which develops from a hematopoietic stem cell.

    This sourceMaps hematopoietic differentiation (stem cell → common myeloid progenitor → myeloblast → mature neutrophil) as an ordered, qualitatively staged, transcription-factor- and cytokine-licensed developmental progression.

    Supported in partVerified against the work's full text

    Review places HSCs atop a progressively restricting progenitor hierarchy that yields mature neutrophils, but never names a myeloblast stage.

    “sit atop a hierarchy of progenitors that become progressively restricted to several or single lineages ( Orkin, 2000 ). These progenitors yield blood precursors devoted to unilineage differentiation and production of mature blood cells, including red blood cells, megakaryocytes, myeloid cells (monocyte/macrophage and neutrophil), and lymphocytes.”

    Read by an automated reader; not a human review. How support was checked

Verification

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Does it back the claim? Read against the text for 1 of 1 citation: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.

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Registry ID ref:eb68b431f04a · see in the full table