Alternating Antibiotic Treatments Constrain Evolutionary Paths to Multidrug Resistance¶
Kim, S., Lieberman, T. D., & Kishony, R. (2014). Alternating Antibiotic Treatments Constrain Evolutionary Paths to Multidrug Resistance. Proceedings of the National Academy of Sciences, 111(40), 14494-14499.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Parrondo's Paradox
- The intervention the prime names — test combinations of individually-failing strategies before discarding them — is precisely what a quant does in discovering that two losing assets compose into a winning rebalanced book, and what a drug-rotation protocol does in alternating antibiotics that each breed resistance alone but suppress it in sequence.
This sourceShows that alternating drugs slows resistance that each drug alone would breed — a Parrondo-type alternation in medicine. Corrected author list (Kim, Lieberman, Kishony — not 'Kim, Sangkeun, et al.'); DOI resolves to this paper; venue, volume/issue, pages confirmed.
Supported in partVerified against the publisher's abstract
The abstract supports that alternating antibiotics slows resistance via trade-offs against a second drug, but not that sequence 'suppresses' resistance or that the claim's Parrondo framing follows from it.
“we find that alternating drugs slows the rate of increase in resistance compared with single-drug treatments, by constraining resistance mutations with trade-offs in resistance to a second drug.”
- The intervention the prime names — test combinations of individually-failing strategies before discarding them — is precisely what a quant does in discovering that two losing assets compose into a winning rebalanced book, and what a drug-rotation protocol does in alternating antibiotics that each breed resistance alone but suppress it in sequence.
Verification¶
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