Alternating Antibiotic Treatments Constrain Evolutionary Paths to Multidrug Resistance¶
Kim, S., Lieberman, T. D., & Kishony, R. (2014). Alternating Antibiotic Treatments Constrain Evolutionary Paths to Multidrug Resistance. Proceedings of the National Academy of Sciences, 111(40), 14494-14499.
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Primes¶
- Parrondo's Paradox
- The intervention the prime names — test combinations of individually-failing strategies before discarding them — is precisely what a quant does in discovering that two losing assets compose into a winning rebalanced book, and what a drug-rotation protocol does in alternating antibiotics that each breed resistance alone but suppress it in sequence.
This sourceShows that alternating drugs slows resistance that each drug alone would breed — a Parrondo-type alternation in medicine. Corrected author list (Kim, Lieberman, Kishony — not 'Kim, Sangkeun, et al.'); DOI resolves to this paper; venue, volume/issue, pages confirmed.
- The intervention the prime names — test combinations of individually-failing strategies before discarding them — is precisely what a quant does in discovering that two losing assets compose into a winning rebalanced book, and what a drug-rotation protocol does in alternating antibiotics that each breed resistance alone but suppress it in sequence.
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