The Protein Cost of Metabolic Fluxes¶
Noor, E., Flamholz, A., Bar-Even, A., Davidi, D., Milo, R., & Liebermeister, W. (2016). The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization. PLoS Computational Biology.
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Primes¶
- Price Mechanism
- Metabolic systems biology uses explicit economic formalisms — metabolite shadow prices from flux-balance duality, enzyme-cost minimization, and protein-allocation trade-offs — that correspond rigorously to marginal values and constraint prices (Reznik, Mehta, and Segrè 2013; Noor et al. 2016
This sourceFormulates enzyme-cost minimization and protein-allocation trade-offs using convex optimization — a mathematically rigorous use of economic "cost" and "allocation" vocabulary in cellular metabolism.
- Metabolic systems biology uses explicit economic formalisms — metabolite shadow prices from flux-balance duality, enzyme-cost minimization, and protein-allocation trade-offs — that correspond rigorously to marginal values and constraint prices (Reznik, Mehta, and Segrè 2013; Noor et al. 2016
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