Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems.¶
Phillips, P. C. (2008). Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems. Nature Reviews Genetics, 9(11), 855-867.
Cited by¶
3 citations across 3 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Conjunctive Path Activation
- In genetics, epistatic interactions express a phenotype only under the AND of specific genotype combinations across loci, the literature explicitly contrasting additive with conjunctive effects.
This sourceContrasts additive with conjunctive (epistatic) genetic effects, where a phenotype expresses only under specific multi-locus genotype combinations.
- In genetics, epistatic interactions express a phenotype only under the AND of specific genotype combinations across loci, the literature explicitly contrasting additive with conjunctive effects.
- Synergy and Antagonism
- Example: two independently beneficial alleles for pathogen resistance interact antagonistically in the field because carrying both reduces overall fitness due to immune system hyperactivation, the kind of negative-epistatic suppression Phillips (2008) catalogues as essential to the structure and evolution of genetic systems.
This sourceComprehensive review of positive and negative epistasis as gene-by-gene synergy and antagonism, including immune-related allelic conflicts and their consequences for fitness.
- Example: two independently beneficial alleles for pathogen resistance interact antagonistically in the field because carrying both reduces overall fitness due to immune system hyperactivation, the kind of negative-epistatic suppression Phillips (2008) catalogues as essential to the structure and evolution of genetic systems.
Domain-specific¶
- Latent-Path Activation
- It is the race condition in concurrency (a latent interleaving that produces corruption only when several timing conditions coincide); the epistatic gene–gene–environment interaction in genetics (disease expressed only under a conjunction of variants and exposures, none pathogenic alone); the drug–drug interaction in pharmacology and toxicology, where the literature even reuses the word "latent pathway" for the same conjunctive-activation shape
This sourceThe genetics co-instance only — epistasis as a phenotype produced by a conjunction of gene variants, none of which acts alone; the review treats gene-gene interaction and does not extend to environmental exposures, to concurrency, or to pharmacology.
- It is the race condition in concurrency (a latent interleaving that produces corruption only when several timing conditions coincide); the epistatic gene–gene–environment interaction in genetics (disease expressed only under a conjunction of variants and exposures, none pathogenic alone); the drug–drug interaction in pharmacology and toxicology, where the literature even reuses the word "latent pathway" for the same conjunctive-activation shape
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