Drug-Induced Prolongation of the QT Interval.¶
Roden, D. M. (2004). Drug-Induced Prolongation of the QT Interval. New England Journal of Medicine, 350(11), 1013-1022.
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Primes¶
- Conjunctive Path Activation
- In pharmacology, a toxic pathway opens only under the AND of multiple drugs on board, a metabolic polymorphism, reduced renal function, and an electrolyte imbalance, each common and benign alone.
This sourceReviews the multifactorial risk structure for drug-induced QT prolongation and torsades de pointes — a toxic pathway realized only under the conjunction of QT-prolonging drugs, metabolic-enzyme inhibition/polymorphism, renal impairment, and electrolyte disturbance (hypokalemia/hypomagnesemia), each common and benign alone; also notes correlated stressors that raise joint risk.
- In pharmacology, a toxic pathway opens only under the AND of multiple drugs on board, a metabolic polymorphism, reduced renal function, and an electrolyte imbalance, each common and benign alone.
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