Dose-Response & Pharmacokinetics

Primes about how a system's response scales with an input dose: threshold, tolerance, and receptor saturation mark regime boundaries, half-life and bioaccumulation track a substance's persistence, and inverted-U response and therapeutic window locate the safe range between too little and too much.

13 primes in this family — primes that sit near one another in abstraction space (k-means over structural-signature embeddings). Each is shown with its short description.

• Bioaccumulation — Progressive concentration.
• Dose-Response Relationship — Input-output mapping.
• Half-Life — Time to halve quantity.
• Hysteresis — Path dependence.
• Inverted-U Response — A response variable rises with a driver, peaks at an interior optimum, then falls — a single-peaked non-monotone relationship in which the same lever that helps below the peak reverses sign and harms above it.
• Linearity — Proportional output.
• Nonlinearity — Disproportionate output.
• PK/PD Modeling (Pharmacokinetics / Pharmacodynamics) — Predict dynamic system behavior.
• Potentiation — One factor enhances another.
• Receptor Saturation — Plateau effects at capacity.
• Therapeutic Window — Optimal input range.
• Threshold — Safe vs harmful levels.
• Tolerance — Reduced effect with repetition.